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Sunday, July 19, 2020 | History

2 edition of Oligonucleotides and Analogues found in the catalog.

Oligonucleotides and Analogues

Fritz Eckstein

Oligonucleotides and Analogues

A Practical Approach (The Practical Approach Series)

by Fritz Eckstein

  • 93 Want to read
  • 26 Currently reading

Published by Oxford University Press, USA .
Written in English


The Physical Object
Number of Pages340
ID Numbers
Open LibraryOL7405876M
ISBN 100199632790
ISBN 109780199632794

This book discusses the chemistry and pharmacokinetics of oligonucleotides and their analogues, and surveys the results of structure-activity studies and current clinical trials. It also critically reviews the problems with antisense therapy, such as the enzymatic destruction of oligonucleotides, the doses required for a therapeutic response. Oligonucleotides are important tools in biochemistry and in molecular and cellular biology. Moreover, oligonucleotides such as antisense oligonucleotides or small interfering RNAs hold promise as.

  Fluorescent nucleic acid base analogues - Volume 43 Issue 2 - L. Marcus Wilhelmsson Skip to main content Accessibility help We use cookies to distinguish you from other users and to provide you with a better experience on our by: Oligonucleotide analogues have recently found wide application in biochemistry and molecular biology as valuable tools for studying interactions of DNA/RNA with other biomolecules [1–3] and as potential candidates for therapeutics in the antisense/antigene or ribozyme strategy [4–6].Author: A. Okruszek.

Peptide nucleic acids (PNAs) are not oligonucleotides and not even DNA analogues, but rather DNA mimics. Chemically PNA is a pseudopeptide in which the individual nucleobase units are amino acids joined together by amide bonds (Figure ) (Nielsen et al., ; Egholm et al., ).Cited by:   Oligonucleotides as Therapeutic Agents - Ebook written by Derek J. Chadwick, Gail Cardew. Read this book using Google Play Books app on your PC, android, iOS devices. Download for offline reading, highlight, bookmark or take notes while you read Oligonucleotides as .


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Oligonucleotides and Analogues by Fritz Eckstein Download PDF EPUB FB2

Interest in oligonucleotide synthesis has expanded dramatically since the publication of M. Gait's book in this series in The process has been automated, new reagents have been developed, and the range of uses for the compounds produced has increased and continues to grow.5/5(2).

Oligonucleotides and analogues: a practical approach. Interest in oligonucleotide synthesis has expanded dramatically since the publication of M. Gait's book in this series in The process has been automated, new reagents have been developed, and the range of uses for the compounds produced has increased and continues to grow.

Oligonucleotides and analogues: a practical approach. [Fritz Eckstein;] Oligonucleotides with Modified Bases, 'The book's twelve chapters provide the reader with a good knowledge of the theory and practice of methods for synthesizing the compounds named in the title.

Interest in oligonucleotide synthesis has expanded dramatically since the publication of M. Gait's book in this series in The process has been automated, new reagents have been developed, and the range of uses for the compounds produced has increased and continues to Size: Oligonucleotides and Analogues book.

Available in the National Library of Australia collection. Format: Book; xxiv, p.: ill. ; 25 cm. Book Review Protocols for Oligonucleotides and Analogs. Synthesis and Properties (Methods in Molecular Biology/20) Edited by Sudhir Agrawal Published The Humana Press Inc., Totowa, NJ pages ISBN 0 7 $ (paperback) Whereas Oligonucleotides and Analogues book of Author: David M.

Tidd. Buy Oligonucleotides and Analogues by Fritz Eckstein from Waterstones today. Click and Collect from your local Waterstones or get FREE UK delivery on orders over £Author: Fritz Eckstein.

Oligonucleotide analogues. We can synthesise a wide range of backbone and sugar-modified oligos such as phosphorothioates, 2′-O-methyl RNA and many others. Please enquire about specific modifications.

Common modifications. Fluorescent probes. Large-scale oligo synthesis. Long oligos. Oligonucleotide analogues containing a novel 2‘- O,3‘- C -linked []bicyclonucleoside have been efficiently synthesized. Enhanced thermal stabilities of duplexes toward both RNA and DNA are reported for a mer oligothymidylate containing 13 modifications and for a nonamer mixed sequence containing three by: Oligonucleotides are short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics.

Commonly made in the laboratory by solid-phase chemical synthesis, these small bits of nucleic acids can be manufactured as. Abstract: The review describes key aspects of the synthesis and biological activities of conjugates of oligonucleotides and their analogues with synthetic peptides, in particular aimed towards gene silencing applications.

The common methods of synthesis of oligonucleotide-peptide conjugates (OPCs) and PNA-peptide conjugates (PPCs) are described Cited by: Oligonucleotides are growing in importance in the pharmaceutical and biotechnology industries as therapeutic medicines.

However, their structure and analysis are challenging and require a different approach to existing medicinal products. This book reviews the most up-to-date analytical strategies for synthetic oligonucleotides.

Like DNA and RNA, PNA oligonucleotides can be labelled with fluorescent dyes during or after solid-phase synthesis. These PNA probes are used in diagnostics and detection. The increased specificity of PNA oligonucleotides in forming hybrid duplexes with DNA and RNA means that mismatched base pairs in hydrid PNA:DNA duplexes are particularly unstable.

Characterization of therapeutic oligonucleotides by liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis, DOI: / Mohammad Elshahawy, Evangelina Pensa, Tim Albrecht, Robert J. Forster. Stepwise electrochemical deposition and single-molecule conductance of nucleic acid by: Book Review in Brief.

Oligonucleotides and analogues: A practical approach. Edited by F Eckstein. pp IRL press at Oxford university press. £ ISBN 0–19––0. J Woodsley. Search for more papers by this author. J Woodsley. Search for more papers by this : J Woodsley. Caruthers M.H. () Synthesis of Oligonucleotides and Oligonucleotide Analogues.

In: Cohen J.S. (eds) Oligodeoxynucleotides. Topics in Molecular and Structural by: 6. The first oligonucleotide analogues which had a regular, predetermined structure containing nucleoside units joined with carbonate, carbamate, hydroxyacetate and hydroxyacetamide tethers have been.

Morpholinoamidines were devised as new cationic units in oligonucleotides, by combining morpholino-nucleosides with internucleoside guanidines.

Here, methodology was developed to accomplish the simplest of objectives, the synthesis of oligonucleotides containing a single morpholinoamidine unit formed by morpholino-uridine Cited by: Current Protocols in Nucleic Acid Chemistry is the comprehensive resource for detailed protocols related to the synthesis, modification, and analysis of modified and unmodified nucleosides, nucleotides, oligonucleotides, and nucleic acids.

Approximately one-third or μmol of the total oligonucleotide synthesis was loaded onto the gel and electrophoresed. The oligonucleotides were visualized by placing the gel directly onto an intensifying screen and illuminating with a short-wavelength ( nm) ultraviolet light.

The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used.Oligonucleotides as Therapeutic Agents.

CIBA Foundation Symposium. ISBN: This book discusses the chemistry and pharmacokinetics of oligonucleotides and their analogues, and surveys the results of structure-activity studies and current clinical trials.Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues.

The book also includes experimental procedures for key reactions related to the synthesis Format: Hardcover.